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Publications

Publications 

[89] Hadji H, Cailleau C, Chassaing B, Ponchel G, Bouchemal K*. Hyaluronan nanoplatelets exhibit extended residence time compared to spherical and ellipsoidal nanomaterials with equivalent surface potentials and volumes after oral delivery in rats. Biomaterials Science, 2024, 12, 5812 - 5823.  https://doi.org/10.1039/D4BM00672K

 

[88] Sumohan Pillai A,# Ben Njima M.A,# Ayadi Y, Cattiaux L, Ladram A, Piesse C, Baptiste B, Gallard J-F, Mallet J-M, Bouchemal K*. Cyclodextrin-based Supramolecular Nanogels Decorated with Mannose for Short Peptide Encapsulation. International Journal of Pharmaceutics, 2024, 660, 12379. https://doi.org/10.1016/j.ijpharm.2024.124379

 

[87] Ahmed Z, Hadji H, Khelifa H, Bourge M, Bouchemal K*. Understanding the interplay between surface properties and the aspect ratio of ellipsoidal nanomaterials. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 680, 132680. https://doi.org/10.1016/j.colsurfa.2023.132680 

 

[86] Suphaphiphat K*, Desjardins D, Lorin V, Diamant N, Bouchemal K, Bosquet N, Mouquet H, Le Grand R, Cavarelli M*. Effective in vivo protection of the broad neutralizing antibody 10-1074 against mucosal cell-associated SHIV infection. Nature Communication, 2023, 14, 6224. https://doi.org/10.1038/s41467-023-41966-4

 

[85] Diaz-Salmeron R, Cailleau C, Denis S, Ponchel G, Bouchemal K*. Hyaluronan nanoplatelets exert an intrinsic anti-inflammatory activity in a rat model of Bladder Painful Syndrome/Interstitial Cystitis. Journal of Controlled Release, 2023, 356, 434-447. https://doi.org/10.1016/j.jconrel.2023.03.014

 

[84] Diaz-Salmeron R, Toussaint B, Cailleau C, Ponchel G, Bouchemal K*. Morphology-dependent bioadhesion and bioelimination of hyaluronan particles administered in the bladder. Advanced NanoBiomed Research, 2022, 2100138 http://doi.org/10.1002/anbr.202100138  

 

[83] Hadji H, Bouchemal K*. Effect of micro- and nanoparticle shape on biological processes. Journal of Controlled Release, 2022, 342, 93-110 https://doi.org/10.1016/j.jconrel.2021.12.032

 

[82] Hadji H, Bouchemal K*. Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems. Advanced Drug Delivery Reviews, 2022, 181, 114101 https://doi.org/10.1016/j.addr.2021.114101

 

[81] Ahmed Z, Ponchel G, Bouchemal K*. Shape stability of ellipsoidal nanomaterials prepared by physical deformation. International Journal of Pharmaceutics, 2021, 609(20), 121178 https://www.sciencedirect.com/science/article/abs/pii/S0378517321009844

 

[80] Diaz-Salmeron R, Michel J-P, Hadji H, Gout E, Vivès R. R, Ponchel G, Bouchemal K*. Role of the interactions of soft hyaluronan nanoparticles with CD44 and supported bilayer membranes in the cellular uptake. Colloids and Surfaces B: Biointerfaces, 2021, 205, 111916 https://doi.org/10.1016/j.colsurfb.2021.111916

 

[79] Diaz-Salmeron R, Da costa A, Michel J-P, Ponchel G, Bouchemal K*. Real-time visualisation of morphology-dependent self-motion of hyaluronic acid nanomaterials in water. International Journal of Pharmaceutics, 2021, 609, 121172 https://doi.org/10.1016/j.ijpharm.2021.121172

 

[78] Malli S, Loiseau P. M, Bouchemal K*. Trichomonas vaginalis motility is blocked by drug-free thermosensitive hydrogel. ACS Infectious Diseases, 2020, 6(1),114-123 https://pubs.acs.org/doi/10.1021/acsinfecdis.9b0024

 

[77] Bouchemal K*, Wong S. S. W, Huang N, Willment J, Latge J-P, Aimanianda V*. β-Glucan grafted microcapsule, a tool for studying the immunomodulatory effect of microbial cell wall polysaccharides. Bioconjugate Chemistry, 2019, 30, 6, 1788-1797. https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.9b00304

 

[76] Malli S, Pomel S, Ayadi Y, Delomenie C, Da Costa A, Loiseau P. M, Bouchemal K*. Topically applied chitosan-coated poly(isobutylcyanoacrylate) nanoparticles are active against cutaneous leishmaniasis by accelerating lesion healing and reducing the parasitic load. ACS Applied Bio Materials. 2019, 2, 6, 2573-2586 https://pubs.acs.org/doi/10.1021/acsabm.9b00263

 

[75] Diaz-Salmeron R, Ponchel G, Bouchemal K*. Hierarchically built hyaluronan nano-platelets have symmetrical hexagonal shape, flattened surfaces and controlled size. European Journal of Pharmaceutical Sciences. 2019, 133, 251-263 https://doi.org/10.1016/j.ejps.2019.04.007

 

[74] Malli S, Pomel S, Donnemont I, Loiseau P.M, Bouchemal K*. Combination of amphotericin B and chitosan platelets for the treatment of experimental cutaneous leishmaniasis: Histological and immunohistochemical examinations. Journal of Drug Delivery Science and Technology. 2019, 50, 34-41. https://doi.org/10.1016/j.jddst.2018.12.031 

 

[73] Malli S, Bories C, Bourge M, Loiseau P.M, Bouchemal K*. Surface-dependent endocytosis of poly(isobutylcyanoacrylate) nanoparticles by Trichomonas vaginalis. International Journal of Pharmaceutics. 2018, 548, 276-287. https://doi.org/10.1016/j.ijpharm.2018.07.006

 

[72] Carn F, Nowak S, Chaab I, Diaz-Salmeron R, Djabourov M*, Bouchemal K. Autoassemblies of alpha-cyclodextrin and grafted polysaccharides: Crystal structure and specific properties of the platelets. The Journal of Physical Chemistry B: Glasses, Colloids, Polymers and Soft Matter. 2018, 122(22), 6055-6063. https://doi.org/10.1021/acs.jpcb.8b01417. Read me

 

[71] Diaz-Salmeron R, Ponchel G, Gallard J-F, Bouchemal K*. Hierarchical supramolecular platelets from hydrophobically-modified polysaccharides and alpha-cyclodextrin: Effect of hydrophobization and alpha-cyclodextrin concentration on platelet formation. International Journal of Pharmaceutics. 2018, 548(1), 227-236, https://doi.org/10.1016/j.ijpharm.2018.06.061

 

[70] Ahmed Z, Malli S, Destruel P-L, Diaz-salmeron R, Da Costa Antonio, Guigner J-M, Porcher F, Benoit B, Ponchel G, Bouchemal K*. New insights on the structure of hexagonally faceted platelets from hydrophobically modified chitosan and alpha-cyclodextrin. International Journal of Pharmaceutics. 2018, 548(1), 23-33. https://doi.org/10.1016/j.ijpharm.2018.06.035

 

[69] Malli S, Bories C, Ponchel G, Loiseau P.M. Bouchemal K*. Phase solubility studies and anti-Trichomonas vaginalis activity evaluations of metronidazole and methylated beta-cyclodextrin complexes: Comparison of CRYSMEB and RAMEB. Experimental Parasitology. 2018, 189:72-75, DOI:10.1016/j.exppara.2018.04.019. Read me

 

[68] Bouchemal K*, Bories C, Loiseau P.M. Strategies for the prevention and the treatment of Trichomonas vaginalis infections. Clinical Microbiology Reviews. 2017, 30(3), 811-825. Read me

 

[67] Grisin T, Bories C, Bombardi M, Loiseau P.M. Rouffiac V, Solgadi A, Mallet J-M, Ponchel G,  Bouchemal K*. Supramolecular chitosan micro-platelets synergistically enhance anti-Candida albicans activity of amphotericin B using an immunocompetent murine model. Pharmaceutical Research. 2017, 34(5), 1067-1082. DOI:10.107/s11095-017-2117-3. Read me

 

[66] Grisin T, Bories C, Loiseau P.M. Bouchemal K*. Cyclodextrin-mediated self-associating chitosan micro-platelets act as a drug booster against Candida glabrata mucosal infection in immunocompetent mice. International Journal of Pharmaceutics. 2017, 519(1-2):381-389. DOI:10.1016/j.ijpharm.2017.01.048. Read me

 

[65] Musumeci G, Bon I, Lembo D, Cagno V, Re MC, Signoretto C, Diani E, Lopalco L, Pastori C, Martin L, Ponchel G, Gibellini D*, Bouchemal K. M48U1 and Tenofovir combination synergistically inhibits HIV-1 infection in activated PBMCs and human cervicovaginal histocultures. Scientific Reports, 2017, 7:41018, DOI:10.1038/srep41018. Read me

 

[64] Malli S, Bories C, Pradines B, Loiseau P.M. Ponchel G, Bouchemal K. In situ forming pluronic F127/chitosan hydrogel limits metronidazole transmucosal absorption. European Journal of Pharmaceutics and Biopharmaceutics. 2017, 112:143-147. DOI: 10.1016/j.ejpb.2016.11.024. Read me

 

[63] Arien K, Baleux F, Desjardins D, Porrot F, Coic Y-M, Michiels J, Bouchemal K, Bonnaffe D, Bruel T, Schwartz O, Le Grand R, Vanham G, Dereuddre-Bosquet N, Lortat-Jacob H*. CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge. Scientific Reports. 2016, 6:34829. DOI:10.1038/srep34829. Read me.

 

[62] Diaz-Salmeron R, Chaab I, Carn F, Djabourov M*, Bouchemal K. Pickering emulsions with alpha-cyclodextrin inclusions: Structure and thermal stability. Journal of Colloids and Interface Science. 2016, 482, 48-57. DOI: 10.1016/j.jcis.2016.07.033 . Read me.

 

[61] Djabourov M*, Bouchemal K. Polymer gels, hydrogels, and scaffolds – An overview. In Descamp M (ed). Disordered Pharmaceutical Materials, Wiley, New York, 2016, pp.241-282. DOI: 10.1002/9783527652693.ch9. Read me.

 

[60] Galus A, Mallet J-M, Lembo D, Cagno V, Djabourov M, Lortat-Jacob H, Bouchemal K*. Hexagonal-shaped chondroitin sulfate self-assemblies have exalted anti-HSV-2 activity. Carbohydrate Polymers. 2016, 136, 113-120. DOI: 10.1016/j.carbpol.2015.08.054. Read me.

 

[59] Pradines B, Djabourov M, Vauthier C, Loiseau P. M, Ponchel G, Bouchemal K*. Gelation and micellization behaviors of pluronic F127 hydrogel containing poly(isobutylcyanoacrylate) nanoparticles specifically-designed for mucosal application. Colloids and Surfaces B: Biointerfaces. 2015, 135, 669-676. DOI: 10.1016/j.colsurfb.2015.08.021. Read me.

 

[58] Pradines B, Lievin-Le-Moal V, Vauthier C, Ponchel G, Loiseau P. M, Bouchemal K*Cell-line-dependent cytotoxicity of (poly(isobutyl cyanoacrylate) nanoparticles coated with chitosan and thiolated chitosan: insights from cultured human epithelial HeLa, Caco2/TC7 and HT-29/MTX cells. International Journal of Pharmaceutics. 2015, 491, 17-20. DOI: 10.1016/j.ijpharm.2015.06.001. Read me.

 

[57] Bouchemal K*, Aka-Any-Grah A, Dereuddre-Bosquet N, Martin L, Lievin-Le-Moal V, Le Grand R, Nicolas V, Gibellini D, Lembo D, Poüs C, Koffi A, Ponchel G. Thermosensitive and mucoadhesive pluronic®/hydroxypropylmethylcellulose hydrogel containing the mini CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervico-vaginal mucus. Antimicrobial Agents and Chemotherapy. 2015, 59(4) 2215-2222. DOI: 10.1128/AAC.03503-14. Read me.

 

[56] Specogna E, Li K-W, Djabourov M*, Carn F, Bouchemal K. Dehydration, dissolution and melting of cyclodextrin crystals. The Journal of Physical Chemistry  B. 2015, 119, 1433-1442. DOI: 10.1021/jp511631e. Read me.

 

[55] Pradines B, Gallard J-F, Iorga B. I, Gueutin C, Ponchel G, Loiseau P. M, Bouchemal K*. The unexpected increase of clotrimazole apparent solubility using randomly methylated beta-cyclodextrin. Journal of Molecular Recognition2015, 28, 96-102. DOI: 10.1002/jmr.2432. Read me

 

[54] Pradines B, Bories C, Vauthier C, Ponchel G, Loiseau P. M, Bouchemal K*. Drug-free nanoparticles are active against Trichomonas vaginalis and non-toxic towards pig vaginal mucosa. Pharmaceutical Research2015, 32, 1229-1236. DOI: 10.1007/s11095-014-1528-7. Read me.

 

[53] Baleux F, Arien K, Desjardins D, Michiels J, Coic Y. M, Connell B. J, Bonnaffé D, Bouchemal K, Le Grand R, Vanham G, Dereuddre-Bosquet N, Lortat-Jacob H*. Mini CD4-heparan sulfate mimetic conjugates display sub nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal route challenge. AIDS research and human retroviruses, 201430(S1), A262-A262. DOI:10.1089/aid.2014.5588.

 

[52] Pradines B, Gallard J-F, Iorga B. I, Gueutin C, Loiseau P. M, Ponchel G, Bouchemal K*. Investigation of the complexation of albendazole with cyclodextrins for the design of new antiparasitic formulations. Carbohydrate Research. 2014, 398, 50-55. DOI: 10.1016/j.carres.2014.06.008. Read me

 

[51] Lembo D, Donalisio M, Laine C, Cagno V, Civra A, Bianchini E.P, Zeghbib N, Bouchemal K*. Auto-associative heparin nanoassemblies: a biomimetic platform against the heparan-sulfate-dependent viruses HSV-1, HSV-2, HPV-16 and RSV. European Journal of Pharmaceutics & Biopharmaceutics. 2014, 88, 275-282. DOI: 10.1016/j.ejpb.2014.05.007. Read me

 

[50] Agostoni V, Anand R, Monti S, Hall S, Maurin G, Horcajada P, Serre C, Bouchemal K, Gref R*. Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(III) metal-organic framework MIL-100(Fe) nanoparticles. J Mater Chem B. 2013, 1, 4231-4242, DOI: 10.1039/c3tb20653j. Read me.

 

[49] Stumpo M, Anselmi C, Vauthier C, Mitri K, Hanno I, Huang N, Bouchemal K*. Scale-up of polyamide and polyester parsol® MCX nanocapsules by interfacial polycondensation and solvent diffusion method. International Journal of Pharmaceutics. 2013, 454(2), 678-685, DOI: 10.1016/j.ijpharm.2013.06.062. Read me.

 

[48] Ravani L, Esposito E, Bories C, Lievien-Le Moal V, Loiseau P. M, Djabourov M, Cortesi R*, Bouchemal K. Clotrimazole-loaded nanostructured lipid carrier hydrogels: Thermal and rheological analyses in the presence of simulated vaginal fluid, in vitro evaluations of cell toxicity and anti-Candida albicans activity. International Journal of Pharmaceutics. 2013, 454(2), 695-702, DOI: 10.1016/j.ijpharm.2013.06.015. Read me.

 

[47] Agostini V, Chalati T, Horcajada, P, Willaime H, Anand R, Semiramoth N, Baati T, Hall S, Maurin G, Chacun H, Bouchemal K, Martineau C, Taulelle F, Couvreur P, Rogez-Kreuz C, Clayette P, Monti S, Serre V, Gref R*. Towards an improved anti-HIV activity of NRTI via metal organic frameworks nanoparticles. Advanced Healthcare Materials. 2013, 2(12) 1630-1637. DOI: 10.1002/adhm.201200454. Read me.

 

[46] Bouchemal K*, Frelichowska J, Martin L, Lienvin-Le-Moal V, Le Grand R, Dereuddre-Bosquet N, Djabourov M, Aka-Any-Grah A, Koffi A, Ponchel G. Note on the formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the miniCD4 M48U1 as anti-HIV-1 microbicide. International Journal of Pharmaceutics. 2013, 454(2), 649-652, DOI: 10.1016/j.ijpharm.2013.02.055. Read me.  

 

[45] Zhang M, Djabourov M, Bourgaux C, Bouchemal K*. Nanostructured fluids from pluronic mixtures. International Journal of Pharmaceutics. 2013, 454(2), 599-610, DOI: 10.1016/j.ijpharm.2013.01.043. Read me

 

[44] Mazzaferro S, Bouchemal K*, Ponchel G. Oral delivery of anti-cancer drugs III: Formulation of anti-cancer drugs using drug delivery systems. Drug Discovery Today. 2013, 18, 99-104. DOI: 10.1016/j.drudis.2012.08.007. Read me

 

[43] Mazzaferro S, Bouchemal K*, Ponchel G. Oral delivery of anti-cancer drugs II: The prodrug strategy. Drug Discovery Today. 2013, 18, 93-98. DOI: 10.1016/j.drudis.2012.08.006. Read me.

 

[42] Mazzaferro S, Bouchemal K*, Ponchel G. Oral delivery of anti-cancer drugs I: General considerations. Drug Discovery Today. 2013, 18, 25-34. DOI: 10.1016/j.drudis.2012.08.004. Read me.

 

[41] Dereuddre-Bosquet N, Morellato L, Brouwers J, Augustijns P, Bouchemal K, Ponchel G, Herrera C, Stefanidou M, Shattock R, Vanham G, Kessler P, Le Grand R, Martin L*. MiniCD4 microbicide gel prevents vaginal transmission of SHIV162P3 in cynomolgus macaques. Plos Pathogen. 2012, 8(12), e1003071. DOI: 10.1371/journal.ppat.1003071. Full text.

 

[40] Mazzaferro S, Bouchemal K*, Skanji R, Gueutin C, Chacun H, Ponchel G. Intestinal permeation enhancement of docetaxel encapsulated into methyl-b-cyclodextrin/poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan. Journal of Controlled Release. 2012, 162, 568-574. DOI: 10.1016/j.jconrel.2012.08.005. Read me.

 

[39] Mitri K, Vauthier C, Huang N, Menas A, Ringard-Lefebvre C, Anselmi C, Stambouli M, Rosilio V, Vachon J-J, Bouchemal K*. Scale-up of nano-emulsion produced by emulsification and solvent diffusion. Journal of Pharmaceutical Sciences-US. 2012, 101(11), 4240-4247. DOI: 10.1002/jps.23291. Read me.

 

[38] Mazzaferro S, Bouchemal K*, Maksimenko A, Skanji R, Opolon P, Ponchel G. Reduced intestinal toxicity of docetaxel into mucoadhesive nanoparticles, in mouse xenograft model. Journal of Colloid Science & Biotechnology. 2012, 1, 210-217. DOI: 10.1166/jcsb.2012.1022. Read me

 

[37] Bouchemal K*, Mazzaferro S.How to conduct and interpret accurately ITC experiments for the cyclodextrin-guest interactions? Drug Discovery Today. 2012, 17, 11-12. DOI: 10.1016/j.drudis.2012.01.023.

 

[36] Hassani L.N, hendra F, Bouchemal K*. Intérêt des polysaccharides amphiphiles auto-associatfs: de la chimie à l'encapsulation de principes actifs. Actualité Chimique. 2012, N°367-368, 94-99.

 

[35] Hassani L.N, Hendra F, Bouchemal K*. Auto-associative amphiphilic polysaccharides as drug delivery systems. Drug Discovery Today. 2012, 17, 623-629. DOI: 10.1016/j.drudis.2012.01.016. 

 

[34] Petit B, Bouchemal K*, Vauthier C, Djabourov M, Ponchel G. The counterbalanced effect of size and surface properties of chitosan-coated poly(isobutylcyanoacrylate) nanoparticle on mucoadhesion due to pluronic F68 addition. Pharmaceutical Research. 2012, 29, 943-952. DOI:10.1007/s11095-011-0634-z. Read me. 

 

[33] Hanno I, Anselmi C, Bouchemal K*. Polyamide nanocapsules and nano-emulsions containing Parsol MCX and Parsol 1789: in vitro release, ex vivo skin penetration and photo-stability studies. Pharmaceutical Research. 2012, 29(2), 559-573. DOI: 10.1007/s11095-011-0592-5. Read me.  

 

[32] Barbieri S*, Sonvico F, Bouchemal K, Ponchel G, Colombo P. Tamoxifen loaded auto-assembled nanoparticles for oral delivery: cytotoxicity and permeability studies. In Rougueda P (ed). NanoFormulation, DOI:10.1039/9781849735247-00070. RSC Publishing, 2012, p70-76.

 

[31] Vauthier C*, Bouchemal K. Processing and scale-up of polymeric nanoparticles. In Prokop A (ed). Intracellular Delivery: Fundamentals and Applications, Fundamental Biomedical Technologies 5, DOI 10.1007/978-94-007-1248-5_16. Springer, 2011, p433-456.

 

[30] Ozcan I*, Bouchemal K, Segura-Sanchez F, Ozer O, Guneri T, Ponchel G. Synthesis and characterization of surface modified PBLG nanoparticles for bone targeting: In vitro and in vivo evaluation. Journal of Pharmaceutical Sciences. 2011, 100(11), 4877-4887. DOI: 10.1002/jps.22678.

 

[29] Mazzaferro S, Bouchemal K*, Gallard J-F, Iorga B.I, Cheron M, Gueutin C, Steinmesse C, Ponchel G. Bivalent sequantial binding of docetaxel to methyl-beta-cyclodextrin. International Journal of Pharmaceutics. 2011, 416(1), 171-180. DOI: 10.1016/j.ijp.2011.06.034.

 

[28] Othman M, Bouchemal K*, Couvreur P, Desmaele D, Morvan E, Pouget T, Gref R. A comprehensive study of the spontaneous formation of nanoassemblies in water by a "lock-and-key" interaction between two associative polymers. Journal of Colloids and Interface Sciences. 2011, 354, 517-527. DOI: 10.1016/j.jcis.2010.11.015.

 

[27] Mazzaferro S, Bouchemal K*, Vauthier C, Gueutin C, Palmieri G-F, Ponchel G. What are parameters affecting Leu-enkephalin loading and release from poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan? Journal of Drug Delivery Science and technology. 2011, 21(5) 385-393

 

[26] Ozcan I*, Segura-Sánchez F, Bouchemal K, Sezak M, Ozer O, Güneri T, Ponchel G. Pegylation of poly(g-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats. Int J Nanomed. 2010, 5, 1103-1111. DOI: 10.1007/s11095-011-0592-5.

 

[25] Sajeesh S, Bouchemal K, Vauthier C, Chandra P Sharma*. Cyclodextrin complexed insulin encapsulated hydrogel microparticles: an oral delivery system for insulin. J Control Release. 2010, 147, 377-384. DOI:/ 10.1016/j.jconrel.2010.08.007. 

 

[24] Daoud-Mahammed S# Agnihotril S#, Bouchemal K, Klöters S, Couvreur P, Gref R*. Efficient loading and controlled release of benzophenone-3 entrapped into self-assembling nanogels. Curr Nanosci. 2010, 6, 1-12. #equally contributing authors.  

 

[23] Aka-Any-Grah A, Bouchemal K*, Koffi A, Agnely F, Zhang M, Djabourov M, Ponchel G. Formulation of mucoadhesive vaginal hydrogels insensitive to dilution with vaginal fluids. Eur J Pharm Biopharm. 2010, 76, 296-303. DOI: 10.1016/j.ejpb.2010.07.004.

 

[22] Sajeesh S, Bouchemal K, Chandra P Sharma, Vauthier C*. Surface functionalized polymethacrylate acid based hydrogel microparticles for oral drug delivery. Eur J Pharm Biopharm. 2010, 74(2), 209-218. DOI: 10.1016/j.ejpb.2009.09.001. 

 

[21] Pilloni M, Nicolas J*, Marsaud V, Bouchemal K, Frongia F, Scano A, Ennas G, Dubernet C. PEGylation and preliminary biocompatibility evaluation of magnetite-silica nanocomposites obtained by high energy ball milling. Int J Pharm. 2010, 401 (1-2), 103-112. DOI: 10.1016/j.ijpharm.2010.09.010. 

 

[20] Segura-Sanchez F, Montembault V, Fontaine L, Martinez-Barboza Ma.E, Bouchemal K, Ponchel G*. Synthesis and Characterization of functionalized poly(γ-benzyl-L-glutamate) derivates and corresponding nanoparticles preparation and characterization. Int J Pharm. 2010, 1-2, 244-252. DOI: 10.1016/j.ijpharm.2009.12.016. 

 

[19] Bouchemal K*, Agnely F, Koffi A, Djabourov M, Ponchel G. What can isothermal titration microcalorimetry experiments tell us about self-organization of surfactants into micelles? J Mol Recognit. 2010, 23, 335-342. DOI: 10.1002/jmr.998. 

 

[18] Bouchemal K*, Couvreur P, Daoud-Mahammed S, Poupaert J, Gref R. A comprehensive study on the inclusion mechanism of benzophenone into supramolecular nanoassemblies prepared using two water-soluble associative polymers. Journal of Thermal Analysis and Calorimetry. 2009, 98, 57-64. DOI: 10.1007/s10973-009-0452-2. 

 

[17] Agüeros M, Ruiz-Gatón L, Vauthier C, Bouchemal K, Espuelas S, Ponchel G, Irache JM*. Combined hydroxypropyl-β-cyclodextrin and poly(anhydride) nanoparticles improves the oral permeability of paclitaxel. European Journal of Pharmaceutical Sciences. 2009, 38(4), 405-413. DOI: 10.1016/j.ejps.2009.09.010.

 

[16] Özcan I*, Bouchemal K, Segura-Sánchez F, Abaci Ö, Özer Ö, Güneri T, Ponchel G. Effects of sterilization techniques on the PEGylated poly (γ-benzyl-L-glutamate) (PBLG) nanoparticles. Acta Pharmaceutica Sciencia. 2009, 51, 211-218.

 

[15] Bouchemal K*, Agnely F, Koffi A, Ponchel G. A concise analysis of the effect of temperature and propanediol-1,2 on Pluronic F-127 micellization using isothermal titration microcalorimetry. Journal of Colloids and Interface Sciences. 2009, 338, 169-176. DOI: 10.1016/j.jcis.2009.05.075. 

 

[14] Othman M, Bouchemal K*, Couvreur P, Gref R. Microcalorimetric investigation on the formation of supramolecular nanoassemblies of associative polymers loaded with gadolinium chelate derivatives. International Journal of Pharmaceutics. 2009, 379, 218-225. DOI: 10.1016/j.ijpharm.2009.05.061. 

 

[13] Roques C, Bouchemal K, Ponchel G, Fromes Y, Fattal E*. Parameters affecting organization and transfection efficiency of amphiphilic copolymer/DNA carriers. Journal of Controlled Release. 2009, 138(1), 71-77. DOI: 10.1016/j.jconrel.2009.04.030.

 

[12] Daoud-Mahammed S, Couvreur P, Bouchemal K, Chéron M, Lebas G, Amiel C, Gref R*. Cyclodextrin and polysaccharide-based nanogels: entrapment of two hydrophobic molecules, benzophenone and tamoxifen. Biomacromolecules. 2009, 10(3), 547-554. DOI: 10.1021/bm801206f. 

 

[11] Segura-Sanchez F, Bouchemal K*, Lebas G, Vauthier C, Santos-Magalhaes N.S and Ponchel G. Elucidation of the complexation mechanism between (+)-usnic acid and cyclodextrins studied by isothermal titration calorimetry and phase-solubility diagram experiments. Journal of Molecular Recognition. 2009, 22, 232-241. DOI: 10.1002/jmr.936. 

 

[10] Vauthier C*, Bouchemal K. Methods for the preparation and manufacturing of polymeric nanoparticles. Pharmaceutical Research. 2009, 26(5), 1025-1058. DOI : 10.1007/s11095-008-9800-3. 

 

[9] Bouchemal K*, Ponchel G, Mazzaferro S, Campos-requena V-H, Gueutin C, Palmieri G-F, Vauthier C. A new approach to determine loading efficiency of Leu-enkephalin in poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan. J Drug Del Sci Tech. 2008, 18 (6), 392-397. DOI:10.1016/S1773-2247(08)50077-3. 

 

[8] Bouchemal K*. New challenges for pharmaceutical formulations and drug delivery system characterization using isothermal titration calorimetry. Drug Discovery Today. 2008, 13 (21-22), 960-972. DOI: 10.1016/j.drudis.2008.06.004.

 

[7] Campos-Requena V-H*, Bouchemal K, Vauthier C, Ponchel G. Encapsulation of leu-enkephalin in core-shell poly(isobutylcyanoacrylate)-thiolated chitosan nanoparticles for oral administration. J Chil Chem Soc. 2008, 54 (3), 1677-1681.

 

[6] Bouchemal K*, Couenne F, Briançon S, Fessi H, Tayakout M. Stability studies on colloidal  suspensions of Polyurethane nanocapsules. J Nanosci Nanotechno. 2006, 6 (9-10), 3187-3192. DOI: 10.1166/jnn.2006.468. 

 

[5] Bouchemal K, Couenne F*, Briançon S, Fessi H, Tayakout M. Polyamides nanocapsules: modelling and wall thickness estimation. AIChE J. 2006, 52 (6), 1-10. DOI: 10.1002/aic.10828. 

 

[4] Bouchemal K, Briançon S, Fessi H, Chevalier Y*, Bonnet I, Perrier E. Simultaneous emulsification and interfacial polycondensation for the preparation of colloidal suspension of nanocapsules. Mat Sci Eng. C. 2006, 26, 472-480. DOI: 10.1016/j.msec.2005.10.022. 

 

[3] Bouchemal K*, Briançon S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: Solvent, oil and surfactant optimization. Int J Pharm. 2004, 280 (1-2), 241-251. DOI: 10.1016/j.ijpharm.2004.05.016. 

 

[2] Bouchemal K*, Briançon S, Perrier E, Fessi H, Bonnet I, Zydowicz N. Synthesis and characterization of polyurethane and poly(ether urethane) nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification. Int J Pharm. 2004, 269 (1), 89-100. DOI: 10.1016/j.ijpharm.2003.09.025.

 

[1] Bouchemal K, Briançon S, Chaumont P, Fessi H, Zydowicz N*. Microencapsulation of Dehydroepiandrosterone (DHEA) with poly (ortho esters) polymers by interfacial polycondensation. J Microencapsul. 2003, 20 (5), 635-651. DOI: 10.1080/026520403100014804.  

 

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